Senior Clinical Research Associate – Oncology – Small Private CRO – East Coast

Location: Remote / Regional – East Coast
Employment Type: Full-Time | Permanent
Salary: $130,000–$155,000 + Benefits
Travel: Up to 65% | Regional Site Monitoring | East Coast
Therapeutic Area: Oncology

Are you an experienced Senior CRA with a strong background in oncology clinical trials looking for an opportunity to take greater ownership of clinical monitoring activities? This is an exciting opportunity to join a well-established, specialist Contract Research Organization, supporting innovative clinical studies focused on advancing treatments within oncology.

We are seeking a proactive, detail-oriented Senior Clinical Research Associate based on the East Coast who can independently manage investigative sites, build strong relationships with clinical teams, and ensure the successful delivery of high-quality clinical trials. You'll have the opportunity to work on specialist oncology studies, take ownership of site monitoring activities, and provide guidance to junior CRAs within a collaborative clinical operations environment.

Key Responsibilities:

• Independently manage clinical trial monitoring activities across regional investigative sites.

• Conduct site qualification, initiation, interim monitoring, and closeout visits.

• Ensure compliance with FDA regulations, ICH-GCP, study protocols, and internal SOPs.

• Review source data, case report forms, and regulatory documentation to ensure data quality and integrity.

• Monitor patient enrolment, protocol deviations, adverse events, and investigational product accountability.

• Build and maintain strong relationships with investigators, study coordinators, sponsors, and clinical teams.

• Identify and resolve site-level operational challenges, data discrepancies, and compliance issues.

• Provide mentorship and technical guidance to junior CRAs.

Candidate Requirements:

• Previous oncology clinical trial monitoring experience – essential.

• Must be based on the East Coast of the United States.

• Proven experience as a Senior CRA or experienced CRA with independent site monitoring responsibilities.

• Strong background within a CRO, pharmaceutical, or biotechnology environment.

• Extensive knowledge of FDA regulations, ICH-GCP, and clinical trial monitoring requirements.

• Experience conducting qualification, initiation, interim, and closeout visits.

• Strong understanding of clinical data review, regulatory documentation, and investigational product management.

• Excellent communication, organization, and problem-solving skills.

• Relevant life sciences or nursing qualification, or equivalent professional experience.

• Willingness to travel up to 65% for regional site monitoring activities.

What's on Offer?

• $130,000–$155,000 base salary.

• Remote / home-based working with regional site travel.

• Medical, dental, and vision insurance.

• Flexible PTO and 401(k) with company match.

• Opportunity to work on specialist oncology clinical trials.

• Professional development and career progression opportunities.